- 53 is an odd prime number.
- 53 is a strange number.
- 53 Stations of the Tōkaidō are the rest areas along the Tōkaidō of the Edo period in Japan. Utagawa Hiroshige created a series of ukiyo-e woodcut prints known as The Fifty-three Stations of the Tōkaidō (in Japanese 東海道五十三次).
In Greek-based number-naming systems, 53 is associated with prefix "triapentaconta-", and with prefix "trequinquaginti-" in Latin systems.